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Table 8 Statistical significance of differences in classification accuracy between quadruple combinations of classfication algorithms and proposed Hybrid algorithm

From: A novel hybrid model to predict concomitant diseases for Hashimoto’s thyroiditis

Classification methods

Proposed hybrid method

Z-test

\(x^2\)-test

p value

SVM-RF-LR-KNN

Hybrid RF-LR-KNN-MLP

14.6

213.1

\(<0\).0001

SVM-RF-LR-MLP

Hybrid RF-LR-KNN-MLP

7.81

61.0

\(<0\).0001

SVM-RF-KNN-MLP

Hybrid RF-LR-KNN-MLP

17.25

306.25

\(<0\).0001

SVM-LR-KNN-MLP

Hybrid RF-LR-KNN-MLP

8.9

79.21

\(<0\).0001

RF-LR-KNN-MLP

Hybrid RF-LR-KNN-MLP

11.8

139.24

\(<0\).0001