EDST: a decision stump based ensemble algorithm for synergistic drug combination prediction

BMC Bioinformatics

Table 3 Classification results of algorithms on the melanoma cell line dataset A375

A375	AUC	F1 score	F1 score*	Recall			Precision			Rank	Rank*
A375	AUC	F1 score	F1 score*	Additive	Antagonism	Synergy	Additive	Antagonism	Synergy	Rank	Rank*
SVM	0.5256	0.3291	0.2164	0.5800	0.2500	0.1714	0.5463	0.2500	0.1950	8.3	9.0
KNN	0.5729	0.3934	0.2678	0.7867	0.1400	0.2286	0.5787	0.5000	0.4800	4.7	5.5
XGB	0.5946	0.3905	0.3104	0.5543	0.3000	0.3714	0.5745	0.2500	0.3274	5.6	4.6
MLP	0.6441	0.3980	0.2921	0.6771	0.3000	0.2286	0.5828	0.2733	0.3800	4.2	4.8
DT	0.5673	0.3330	0.2679	0.4305	0.3429	0.2500	0.5152	0.2756	0.2133	7.0	5.6
GDBT	0.6574	0.3538	0.2620	0.5552	0.2857	0.2500	0.5635	0.2530	0.2600	6.1	5.8
RF	0.6569	0.4000	0.3070	0.6762	0.2000	0.3143	0.5789	0.3300	0.4321	3.8	4.0
Single-layer Network	0.5086	0.2242	0.0994	0.6000	0.2857	0.0500	0.4325	0.1288	0.0125	9.2	10.0
DeepSynergy	0.5071	0.3791	0.2345	0.8124	0.1500	0.2286	0.6037	0.3000	0.3167	5.8	7.8
MatchMaker	0.5120	0.2124	0.2346	0.3000	0.4800	0.1500	0.1435	0.3308	0.0429	8.3	7.0
EDST	0.6625	0.4680	0.4220	0.5286	0.5143	0.3900	0.6216	0.4593	0.3319	2.5	1.6

ISSN: 1471-2105