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Fig. 6 | BMC Bioinformatics

Fig. 6

From: Designing and development of multi-epitope chimeric vaccine against Helicobacter pylori by exploring its entire immunogenic epitopes: an immunoinformatic approach

Fig. 6

A The docked complex of TLR2 with the vaccine construct exhibits a binding energy of − 23.45 kcal/mol indicating the strength of interaction. (I, II) The structure of the complex is visualised by Pymol software, which enables a view of the spatial arrangement and and interaction of the TLR2 receptor (Chain A) and the vaccine construct (Chain B) within the complex. (III) The interaction between the two molecules is further examined using LigPlot + , which provides an insightful visualization of the specific interactions and binding interfaces between TLR2 and the vaccine. B The docked complex of TLR4 with the vaccine construct shows a binding energy of − 25.87 kcal/mol. (I, II) The structure is visualized using Pymol software. (III) The interaction is visualized using LigPlot + (Chain A—TLR and Chain B—Vaccine construct). C A docked complex of TLR5 with the vaccine construct demonstrates a binding energy of − 33.24 kcal/mol. (I, II) The structure is visualized using Pymol software. (III) The interaction is visualized using LigPlot + (Chain A—TLR and Chain B—Vaccine construct)

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BMC Bioinformatics

ISSN: 1471-2105

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