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Fig. 8 | BMC Bioinformatics

Fig. 8

From: Designing and development of multi-epitope chimeric vaccine against Helicobacter pylori by exploring its entire immunogenic epitopes: an immunoinformatic approach

Fig. 8

C-ImmSim presentation of an in silico immune simulation with the constructed vaccine. A Increased immunoglobulin production in response to the vaccine injection, indicating an immune response. B The population dynamics of B cells following the three vaccine injections, provide insights into the immune response generated by the vaccine. C The evolution of the TH cell population, with each vaccine injection, over the course of the immune simulation. However, the population decreases when the concentration of antigen decreases. D The populations of T-cytotoxic cells in different states following the vaccine injections, indicating their involvement in the immune response elicited by the vaccine. E The TH memory cell population, shows its changes over time. The memory cell population increases specifically after the third injection, while the total cell population continues to increase with each injection. F The levels of cytokines, measured by the Simpson index, following the three vaccine injections

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BMC Bioinformatics

ISSN: 1471-2105

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