Table 1 Comprehensive list of H. pylori proteins selected for the design of a potential vaccine each protein is accompanied by its respective accession ID and HTL cell epitopes
H. pylori protein | Accession Id | MHCII epitopes | Alleles | % Binding | IFN-y | Antigenic score |
|---|---|---|---|---|---|---|
Hop family outer membrane protein HopL | WP_000591195.1 | KHESLRAYENAKDYD | HLA-DQA10102-DQB10401 | 0.27 | Positive | 0.6429 |
HLA-DQA10103-DQB10202 | 1.1 | |||||
HLA-DPA10201-DPB10901 | 1.23 | |||||
GEIYNMYAHTAAHKT | HLA-DQA10102-DQB10401 | 0.17 | Positive | 0.7245 | ||
HLA-DQA10103-DQB10202 | 1.46 | |||||
HLA-DQA10103-DQB10202 | 2.45 | |||||
Hop family adhesin HopQ | WP_000751487.1 | ISNVYSAKVNTANFQ | HLA-DQA10102-DQB10401 | 0.16 | Positive | 1.2648 |
HLA-DQA10103-DQB10202 | 1.39 | |||||
ARPKKKDSHHAAQHG | HLA-DPA10201-DPB10901 | 1.59 | Positive | 1.1025 | ||
HLA-DQA10103-DQB10202 | 2.46 | |||||
HLA-DQA10102-DQB10401 | 2.58 | |||||
Flagellar hook protein FlgE | WP_001000224.1 | NEPIDAITNRKLNIS | HLA-DQA10103-DQB10202 | 1.27 | Positive | 0.4278 |
HLA-DQA10102-DQB10401 | 1.47 | |||||
SNNIANVNTLGYRSN | HLA-DQA10103-DQB10202 | 1.13 | Positive | 0.7005 | ||
HLA-DQA10102-DQB10401 | 1.8 | |||||
Flagellin A | WP_000885486.1 | NSNQTGVRAHASVIT | HLA-DPA10201-DPB10901 | 1.17 | Positive | 1.3663 |
HLA-DQA10102-DQB10401 | 0.93 | |||||
SGANYNAVIASGNQN | HLA-DQA10102-DQB10401 | 0.51 | Positive | 0.7481 | ||
HLA-DQA10103-DQB10202 | 1.95 | |||||
HLA-DQA10102-DQB10401 | 1.4 | |||||
Outer membrane protein | WP_000971468.1 | HTNFSNSRAANAISP | HLA-DQA10102-DQB10401 | 0.91 | Positive | 0.6775 |
HLA-DQA10103-DQB10202 | 2.51 | |||||
ATAGFFVGVNFAGNT | HLA-DPA10105-DPB10801 | 1.53 | Positive | 0.4978 | ||
HLA-DPA10105-DPB10801 | 0.78 | |||||
Septal ring lytic transglycosylase RlpA family protein | WP_000521812.1 | QAYLRSAGADVSYRR | HLA-DQA10102-DQB10401 | 1.51 | Positive | 0.7258 |
HLA-DQA10102-DQB10401 | 2.65 | |||||
ARNQVQNAQNQANNY | HLA-DQA10102-DQB10401 | 2.121096 | Positive | 0.4865 | ||
HLA-DQA10102-DQB10401 | 0.118137 |