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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Bulk brain tissue cell-type deconvolution with bias correction for single-nuclei RNA sequencing data using DeTREM

Fig. 1

Study design. Bulk RNA-seq data were simulated using real snRNA-seq data. Cell fraction estimates of the simulated and real bulk RNA-seq data were calculated using several MuSiC software variations, SCDC, CIBERSORTx, and a DeTREM. Next, the accuracy of the cell fraction proportions obtained using each deconvolution method for each dataset was determined by comparisons with experimentally derived data as follows: (1) simulated bulk RNA-seq data were compared to true cell fractions, (2) ROSMAP brain data were compared to matched IHC measurements, and (3) FHS/BUADRC brain data were compared to matched Iba1 + density measurements

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BMC Bioinformatics

ISSN: 1471-2105

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