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Fig. 3 | BMC Bioinformatics

Fig. 3

From: CrMP-Sol database: classification, bioinformatic analyses and comparison of cancer-related membrane proteins and their water-soluble variant designs

Fig. 3

Superposed AlphaFold2 predicted 5 cancer-related membrane proteins (green) with their water-soluble QTY variants (cyan). Side view and top view are presented. For clarity, both extracellular and intracellular regions are removed. A MGAT3 versus MGAT3QTY (RMSD: 0.157, 0.309 (TM)), B GPR35 versus GPR35QTY (RMSD: 1.478, 1.044 (TM)), C GPR37 versus GPR37QTY (RMSD: 1.216, 0.899 (TM)), D SLC10A1 versus SLC10A1QTY (RMSD: 1.233, 0.544 (TM)), and E NPC1L1 versus NPC1L1QTY (RMSD: 0.656, 0.603 (TM)). F RMSD distribution of the 1309 QTY designs for all cancer-related membrane proteins in the database. Each dot represents a QTY design, with the RMSD value corresponding to the distance from the origin. The angle in the polar coordinate system represents the degree of the secondary structure change. Higher angles in respect to the horizontal line represents greater secondary structure change. A color gradient represents the molecular weight of each protein

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BMC Bioinformatics

ISSN: 1471-2105

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