Fig. 1

The synonymous mutation rate in cancer varies across patients, histology types, and genes. A Box plot (Top) of patient synonymous mutation frequency across all histology types. Mutation frequency is shown as a logarithmically transformed mutation number per mega base pair. Patients that don’t have any synonymous mutations are set to have -2 transformed mutation frequency per mega base pair. Each dot represents a patient. Histology types are ordered by their median somatic mutation frequency. The relative percentage (bottom) of mutations falls into 6 mutation categories (see Methods Section) for all individual patients across the histology types. B Synonymous mutation number averaged by number of patients in Ovary-AdenoCA (blue), Lung-SCC (orange), and Thy-AdenoCA (green), respectively, illustrated on the entire chromosome 8 (top) and chromosome 18 (bottom)