Fig. 4

Synonymous mutations are significantly enriched in BCL-2’s BH4 motif. A Illustration and distribution of all BCL-2 synonymous mutations identified in PCAWG Lymph-BNHL patients across the BCL-2 coding sequence. Circles represent the occurrence of each synonymous mutation. BCL-2 motifs and the synonymous mutation in those motifs are colored: BH4 (Orange), BH3 (Blue), BH1 (Brown), and BH2 (Bright Pink). No synonymous mutations were observed in BH2 motif. Synonymous mutations that fall outside of the motifs are colored grey. B BH4 synonymous mutation number distribution from permutation test (10,000 permutations). The red line shows the observed number of synonymous mutations (n = 9)