Fig. 6
From: Efficient design of synthetic gene circuits under cell-to-cell variability
Viable samples in the population parameter space for reference curves with extended IDR. Samples in all two-dimensional projections of the parameter space, obtained with the SLMCMC algorithm for individual threshold \(\varepsilon = 6\,\textrm{nM}\) and diagonal covariance matrix. Orange dots: IDR up to \(150\,\textrm{nM}\); red dots: IDR up to \(300\,\textrm{nM}\); purple dots: IDR up to \(450\,\textrm{nM}\) nM. Non-viable population samples (i.e. \(c(\gamma ) > 0.2\)) were removed prior to plotting. All parameters were sampled in \(\hbox {log}_{10}\)-scale, and are displayed as such. Top-right corner: Corresponding viable population dose-response curves. Black line: reference curve up to \(450\,\textrm{nM}\). Colored lines corresponding to sample colors: 50 population dose-response curves per reference curve, computed as in Fig. 2C from 50 samples of population parameters. Colored boxes delimit the portion of the black line used as a reference curve during population design