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Fig. 4 | BMC Bioinformatics

Fig. 4

From: Detection of continuous hierarchical heterogeneity by single-cell surface antigen analysis in the prognosis evaluation of acute myeloid leukaemia

Fig. 4

Differentiation orientation pinpoint with the reference of typical trajectory. a Time-series heatmap of sample no. 569255 could not pinpoint the trajectory direction without CD45high/CD11b+ cluster landmark; b time-series heatmap of sample no. 326944 (trajectory with typical mature blast at right terminal) as reference trajectory; c dissimilarity heatmap of sample no. 326944 and reverse sample no.569255 trajectory; d dissimilarity heatmap of sample no. 326944 and correct sample no.569255 trajectory; e, f trajectory inference with local reverse did not match with the sample on dissimilarity matrix. Red frame emphasized the error-directed local; g, h correct trajectory direction with a diagonal presentation. Red frame emphasized the local with correct direction

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BMC Bioinformatics

ISSN: 1471-2105

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