Table 1 Characteristics of IBS cluster analysis articles
From: Subtyping irritable bowel syndrome using cluster analysis: a systematic review
Study, year [reference] | Study design | Population | Diagnostic criteria | Variables | Data collection |
|---|---|---|---|---|---|
Black et al. 2021 [59] | Cross-sectional (two groups of patients) | 1375 IBS patients: mean age, 49.2 (18–86); 1157 females (84.1%); 1080 met ROME III; 811 met ROME IV | ROME III or ROME IV | Gastrointestinal (GI) symptoms, mood, extraintestinal symptoms, GI symptom-specific anxiety, stress | IBS-SSS, PHQ-12, HADS-A, HADS-D, CPSS, VSI |
Han et al. 2019 [60] | Cross-sectional (two groups) | 332 IBS patients aged 18–70 (283 females, 85.2%), 224 patients in group 1 mean age 43.4 (193 females, 86.2%) 108 patients in group 2 mean age 39.7 (90 females, 83.3% | ROME II in group 1 ROME III in group 2 | Daily diary of GI and non-GI symptoms, cognitive beliefs, QoL | 26-item daily diary, CSFBD, 42-item IBS QoL scale |
Lackner et al. 2013 [61] | Cross-sectional (1 group) | 98 IBS patients mean-aged 46.7 (female 88%) | ROME II | GI symptoms, QoL | IBS-SSS, UCLA-SSS |
Nevé et al. 2013 [63] | Randomized Clinical Trial (RCT) | 43 IBS patients aged 18–71(35 female), 29 healthy controls aged 22–62 (20 female) | ROME III | GI symptoms, psychological symptoms, exhaled H2 and CH4 | GSRS, HAD, QuinTron Breath Tracker (measure exhaled H2 and CH4) |
Eslick et al. 2004 [42] | Cross-sectional | 897 patients: mean aged, 44; 577 females (64%); 212 IBS patients (24.5%) | Diagnose by the physicians | GI symptoms | BDQ |
Guthrie et al. 2003 [51] | Prospective cohort study (2 groups) | 107 IBS patients aged 18–65 (88 females, 82%) and 23 healthy controls aged 20–45 (17 females) | ROME I | Bowel symptoms, psychological assessments, QoL, physiological assessments | BDQ, 11-items Lickert Scale, SCAN, SCL-90-R, a validated screening questionnaire developed by Leserman and colleagues, IIP-32, SF-36, well-lubricated tube for sensory response to rectal distention |
Ragnarsson et al. 1999 [52] | Prospective cohort (2 groups) | 2 samples Sample 1: 63 IBS patients aged 17–74 (40 females,23 male) Sample 2: 52 IBS patients aged 19–76 (39 females, 13 males) | ROME I | Bowel habits, pain, and, bloating | Daily records of their symptoms for 6 weeks in sample 1 and a week in sample 2 |
Howard Mertz et al. 1995 [57] | Prospective cohort study (2 groups) | 100 IBS patients mean aged 44 (22–88), 69 females 15 healthy controls mean aged 37 (28–50), 7 females | ROME criteria | Anorectal sensory, motor function, GI, and psychological symptoms | The volume-displacement device, anorectal manometry, BDQ, SCL-90 |
Ragnarsson et al. 1999 [53] | Prospective cohort study | 52 IBS patients aged 19–76 | Confirmed the diagnosis by gastroenterologist and ROME criteria | Anal sphincter function, anal canal motility, the sensory function of the rectum, RAIR, rectal reservoir function, and rectal motility. GI symptoms, pain, and distention | 1-week diary record card, pre and postprandial anorectal manovolumetry |
Bouchoucha et al. 1999 [54] | Prospective cohort Study (2 groups) | 60 IBS patients aged 21–72 (4 males, 7%) 20 healthy control females aged 22–65 | ROME criteria | Anal pressure waves in rest and distention state | Standard manometry |
Bouchoucha et al. 2006 [55] | Prospective cohort study (2 groups) | (148 healthy controls and 1385 IBS patients) | ROME II | Colon Transit Time (CTT) | CTT by Prodimed Le Plessis-Bouchard |
Bennet et al. 2018 [62] | Cross-sectional (2 groups) | 246 IBS patients mean-aged 33 (25–45) (77.2% female), 21 healthy control mean-aged 30 (26.5–43.5) (100% female) | ROME II | Systemic cytokines level, colonic sensory and motility testing, individual assessment questionnaire | High sensitivity multiplex assays, a combined mano-reentry and a barostat, IBS-SSS, IBS QoL, comorbid conditions, brief symptom inventory |
Johanna Sundin et al. 2019 [56] | Prospective cohort (2 groups) | 43 IBS patients aged 25–44, 20 healthy controls aged 24–38 | ROME III | Visceral sensitivity, IgE levels, IBS symptoms, mood, mast cell microscopy and quantification, fecal protease activity assay, mucosal gene expression analysis | Immunoassay, dual drive barostat, IBS_SSS, GSRS-IBS, HADS, VSI, immuno-fluorescence, quantitative reverse transcription PCR |
Ian et al. 2014 [58] | Prospective cohort study (2 groups) | 37 patients: mean age, 37; 26 females 20 healthy controls (matched age and gender) | ROME II | Microbial composition, GI and psychological symptoms, QoL, rectal sensitivity test, and, CTT | Bioinformatics processes, HADS, GSRS-IBS, SF_36, BSFS, rectal barostat, radio-opaque markers |