Table 1 20 known relationships in the knowledge graph network
Relationship | Species | Database | Total interactions |
|---|---|---|---|
Gene-disease | SARS-CoV-2 | CTD database [61] | 28 |
Gene-drug | Homo-sapiens | CTD database [61] | 9291 |
Protein–drug | Homo-sapiens | DrugBank [44] | 20, 992 |
Protein–protein | Homo-sapiens | STRING database [55] | 11,606735 |
Protein–protein | Mus-musculus | STRING database [55] | 10, 016742 |
Protein-GOT CC | Mus-musculus | UniProt-GOA [62] | 69, 373 |
Protein-GOT BP | Mus-musculus | UniProt-GOA [62] | 125, 658 |
Protein-GOT MF | Mus-musculus | UniProt-GOA [62] | 56, 322 |
Protein-GOT CC | Homo-sapiens | UniProt-GOA [62] | 65, 295 |
Protein-GOT BP | Homo-sapiens | UniProt-GOA [62] | 101, 177 |
Protein-GOT MF | Homo-sapiens | UniProt-GOA [62] | 54, 638 |
Protein-gene | SARS-CoV-2 | UniProt [47] | 18, 387 |
Protein-gene | Homo-sapiens | UniProt [47] | 195, 659 |
Protein-gene | Mus-musculus | UniProt [47] | 110, 421 |
Anatomy-gene | Homo-sapiens | Hetionet [54] | 726, 495 |
Gene-pathway | Homo-sapiens | Hetionet [54] | 84, 372 |
Drug-side effect | Homo-sapiens | Hetionet [54] | 138, 944 |
Drug-gene | Homo-sapiens | GNBR [53] | 80, 803 |
DrugBank [44] | 24, 801 | ||
IntAct [63] | 1, 805 | ||
DGIdb [52] | 26, 290 | ||
Hetionet [54] | 51, 429 | ||
Bibliography | 25, 666 | ||
Disease-gene | Homo-sapiens | GNBR [53] | 95, 399 |
Hetionet [54] | 27, 977 | ||
Bibliography | 461 | ||
Drug-disease | Homo-sapiens | Drugbank [44] | 4, 968 |
GNBR [53] | 77, 782 | ||
Hetionet [54] | 1, 145 |