Table 12 Top 10 predicted novel interactions in the GPCR dataset performed by DTIOG-BaggingClassifier, with supporting evidence from external databases
Rank | Drugbank ID | Drug name | Uniprot ID | Target name | Evidence |
|---|---|---|---|---|---|
1 | DB00810 | Biperiden | P20309 | Muscarinic acetylcholine receptor M3 | KEGG |
2 | DB00726 | Trimipramine | P08912 | Muscarinic acetylcholine receptor M5 | DrugBank |
3 | DB00850 | Perphenazine | P21918 | D(1B) dopamine receptor | KEGG |
4 | DB00568 | Cinnarizine | P08173 | Muscarinic acetylcholine receptor M4 | DrugBank, KEGG |
5 | DB00726 | Trimipramine | P28223 | 5-hydroxytryptamine receptor 2A | DrugBank, KEGG |
6 | DB00568 | Cinnarizine | P20309 | Muscarinic acetylcholine receptor M3 | DrugBank, KEGG |
7 | DB00462 | Methscopolamine bromide | P20309 | Muscarinic acetylcholine receptor M3 | DrugBank, KEGG |
8 | DB01239 | Chlorprothixene | P20309 | Muscarinic acetylcholine receptor M3 | DrugBank, KEGG |
9 | DB00933 | Mesoridazine | P20309 | Muscarinic acetylcholine receptor M3 | KEGG |
10 | DB00454 | Meperidine | Q9H3N8 | Histamine H4 receptor | KEGG |