Table 13 Top 10 predicted novel interactions in the IC dataset performed by DTIOG-BaggingClassifier, with supporting evidence from external databases
Rank | Drugbank ID | Drug name | Uniprot ID | Target name | Evidence |
|---|---|---|---|---|---|
1 | DB00653 | Magnesium sulfate | Q01668 | Voltage-dependent L-type calcium channel subunit alpha-1D | DrugBank |
2 | DB00349 | Clobazam | P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | DrugBank, KEGG |
3 | DB00818 | Propofol | O75311 | Glycine receptor subunit alpha-3 | KEGG |
4 | DB01122 | Ambenonium | P46098 | 5-hydroxytryptamine receptor 3A | None |
5 | DB01239 | Chlorprothixene | Q92952 | Small conductance calcium-activated potassium channel protein 1 | None |
6 | DB00312 | Pentobarbital | Q15878 | Voltage-dependent R-type calcium channel subunit alpha-1E | None |
7 | DB00829 | Diazepam | O75311 | Glycine receptor subunit alpha-3 | KEGG |
8 | DB00653 | Magnesium sulfate | Q00975 | Voltage-dependent N-type calcium channel subunit alpha-1B | None |
9 | DB00740 | Riluzole | Q13002 | Glutamate receptor ionotropic, kainate 2 | KEGG |
10 | DB00949 | Felbamate | O75311 | Glycine receptor subunit alpha-3 | KEGG |