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Fig. 1 | BMC Bioinformatics

Fig. 1

From: ICON-GEMs: integration of co-expression network in genome-scale metabolic models, shedding light through systems biology

Fig. 1

Workflow diagram representing the process of ICON-GEMs to integrate a gene co-expression network into a genome-scale metabolic model. It starts with gene expression profiles and genome-scale metabolic models. Data cleaning and processing are applied to the gene expression data to construct a gene co-expression network. The template model is constructed, and gene-protein-reaction (GPR) rule is used to quantify the associated reactions. Finally, a gene co-expression network and a metabolic network are merged for calculating flux rates in ICON-GEMs formulation

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BMC Bioinformatics

ISSN: 1471-2105

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