Fig. 4

Model performance on known and simulated altORFs. A–E Well-characterized examples of alternative translation events are correctly inferred by the model. The annotated and predicted ORF are shown schematically above the real \(\rho _i^t\) signal for each transcript. Sensitivity (F) and specificity (G) are shown for sequences simulated using parameters estimated from the Wu et al. S. cerevisiae data set [38]. Each point represents the mean sensitivity or specificity over 100 simulated sequences with the given mean ribo-seq coverage. H The number of ORFs with at least the given ribo-seq coverage drops off rapidly as the coverage threshold increases. The data shown are for the Wu et al. S. cerevisiae data set [38]