Fig. 2

Convergence comparison of ADSB and HR in E. coli core metabolic models with varying number of potentially active closed loops. Correlation between flux means (A) and standard deviations (B) between both samplers in all models. Synthetic models R0, R2, R10 and R12 contain 0, 2, 10 and 12 potentially active closed loops, respectively. The reactions forced to be reversible to generate these models can be found in Section 6 of the Additional file 1. C Comparison of the convergence behavior of ADSB and HR. Each model was simulated on minimal medium growing aerobically. Both algorithms were run under the same conditions: \(2 \cdot 10^{5}\) final points, 100 steps per point (thinning), and first \(2 \cdot 10^{4}\) points discarded (burn-in)