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Fig. 4 | BMC Bioinformatics

Fig. 4

From: PASTRY: achieving balanced power for detecting risk and protective minor alleles in meta-analysis of association studies with overlapping subjects

Fig. 4

Comparison of p-value ratios of A PASTRY method and B LS method over the splitting approach for diabetes mellitus dataset from UK Biobank data. The x-axis shows the odds ratios (ORs) of the significant loci, and the y-axis shows the p-value ratios. The green boxes show the p-value ratios for the risk minor alleles, and the pink boxes show the p-value ratios for the protective minor alleles. The protective minor alleles and risk minor alleles were divided into three ranges each (protective: − 1/1.20, 1/1.20–1/1.0,1/1.10–1.00 and risk: 1.00–1.10, 1.10–1.20, 1.20− ). The blue dashed line represents y = 1, where the two methods’ p-values are the same

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BMC Bioinformatics

ISSN: 1471-2105

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