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Table 1 General information on the tested pathway activity inference methods

From: Robustness evaluations of pathway activity inference methods on gene expression data

Method

Description

Category

Pathway representation

References

COMBINER

Multi-level optimisation framework for core module inference

Non-TB

GS

[31]

PAC

Pathway activity inference scheme in a condition-specific manner

Non-TB

GS

[16]

PLAGE

Pathway level analysis of gene expression based on singular value decomposition (SVD)

Non-TB

GS

[32]

GSVA

Gene set enrichment based on Kolmogorov Smirnov-like random statistic

Non-TB

GS

[33]

DRW

Random walk restart on KEGG network

PTB

PT

[13]

sDRW

Random walk restart on KEGG network

PTB

PT

[34]

e-DRW

Bi-random walk restart on KEGG and NCI-PID network separately

PTB

PT

[35]

  1. non-TB: non-topology based method, PTB: pathway topology based method; GS: gene set, PT: pathway topology.