Fig. 2
From: Predicting microbial interactions with approaches based on flux balance analysis: an evaluation
Overview of the process in this analysis: The three software tools (MICOM, MMT and COMETS) were validated using 18 semi-refined models from AGORA (Am) and four refined (i.e. manually curated) models (Rm). Predictions were carried out using in vitro media matching the composition of the media in the experiments with the uptake flux bound values (mmol/gDW/h). The predicted monoculture growth rates were compared to growth rates derived from experimental growth curves as the slope of the exponential phase in log scale. Finally, ratios of growth rates or maximal abundance (the latter only in COMETS) in co- and monoculture were compared to corresponding experimental data in co- and monoculture to evaluate the accuracy of interaction strength prediction