Fig. 5

PowerAnalysis. (a) A diagram showing the workflow of power analysis based on simulation. (b) Type 1 error over cohort size for the 3 models, global, GAMLSS adjusted, and regularized. The red line indicates a type 1 error rate of 5 percent, which is considered a well-controlled error rate for this analysis. The blue and green lines show approximately where the model reaches the well-controlled type 1 error. (c) Power analysis over cohort size for the 3 models. The global model, while well-controlled at very small cohort sizes, has very low statistical power. The GAMLSS adjusted model, while having very high statistical power, requires a large cohort to control type 1 error. The regularized model controls for type 1 error at a cohort size smaller than that available to this study while still greatly improving the statistical power over the global model