Table 3 Comparison of the number of essential proteins identified by 12 node ranking methods on the S-PIN, D-PIN, RD-PIN and the CM-PIN at top 100–600 on YBioGRID dataset

LAC

[43,104,159,

217,277,325]

[43,123,189,

256,314,351]

[54,100,175,

236,287,334]

[54,138,209,

265,316,365]

[57,103,180,

241,290,339]

[57,137,215,

271,323,380]

DC

[54,99,149,

208,254,298]

[55,110,181,

241,295,343]

[55,108,172,

231,278,310]

[56,122,189,

254,295,339]

[61,128,196,

244,289,341]

[62,129,205,

261,317,367]

DMNC

[25,81,144,

183,225,267]

[46,107,173,

227,274,316]

[34,94,161,

204,251,303]

[55,126,190,

237,292,332]

[28,95,157,

207,253,307]

[55,132,191,

237,295,350]

NC

[42,110,165,

217,270,321]

[44,130,192,

257,317,370]

[53,108,176,

245,299,343]

[55,135,216,

274,320,375]

[56,109,183,

245,300,347]

[57,140,215,

278,328,379]

TP

[48,86,132,

180,218,250]

[57,108,171,

227,283,332]

[45,105,147,

186,221,252]

[55,115,178,

237,293,329]

[70,134,192,

247,302,339]

[70,136,196,

249,300,341]

LID

[43,103,157,

219,276,324]

[43,122,189,

259,319,357]

[55,99,173,

243,287,334]

[55,137,212,

269,312,364]

[57,102,179,

247,293,340]

[57,138,217,

273,326,374]

BC

[47,95,141,

175,204,248]

[69,129,175,

232,270,317]

[47,86,141,

186,222,259]

[54,110,159,

209,262,304]

[41,81,123,

174,216,260]

[47,89,138,

190,229,279]

CC

[39,69,99,

128,161,184]

[61,104,151,

197,249,292]

[31,63,89,

115,140,178]

[51,97,146,

193,241,279]

[50,91,143,

193,237,273]

[50,91,141,

197,239,273]

PR

[51,106,150,

190,238,286]

[64,120,177,

239,286,341]

[55,105,156,

201,257,298]

[60,113,176,

232,285,333]

[61,121,179,

226,264,307]

[64,131,183,

238,278,336]

LR

[54,99,133,

165,197,226]

[59,105,157,

202,241,276]

[54,99,141,

164,190,223]

[62,102,141,

184,222,226]

[56,112,152,

184,218,253]

[58,116,161,

196,232,266]

PeC

[59,97,172,

232,280,325]

[61,135,202,

261,309,352]

[60,101,174,

230,278,317]

[61,134,203,

256,305,341]

[63,101,176,

235,286,327]

[63,138,207,

263,314,354]

WDC

[53,110,163,

229,283,326]

[56,126,199,

262,311,362]

[56,115,169,

235,283,323]

[58,131,210,

263,313,355]

[60,108,186,

248,292,347]

[62,135,213,

273,328,381]