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Volume 10 Supplement 8

Proceedings of the European Conference on Computational Biology (ECCB) 2008 Workshop: Annotations, interpretation and management of mutations (AIMM)

Research

Edited by Christopher JO Baker and Dietrich Rebholz-Schuhmann

ECCB 2008 Workshop: Annotations, interpretation and management of mutations (AIMM). Go to conference site.

Cagliari, Italy22 September 2008

  2. There is a considerable interest in characterizing the biological role of specific protein residue substitutions through mutagenesis experiments. Additionally, recent efforts related to the detection of diseas...

    Authors: Martin Krallinger, Jose MG Izarzugaza, Carlos Rodriguez-Penagos and Alfonso Valencia
    Citation: BMC Bioinformatics 2009 10(Suppl 8):S1
    Content type: Research Published on:

  3. A better understanding of the mechanisms of an enzyme's functionality and stability, as well as knowledge and impact of mutations is crucial for researchers working with enzymes. Though, several of the enzymes...

    Authors: Süveyda Yeniterzi and Uğur Sezerman
    Citation: BMC Bioinformatics 2009 10(Suppl 8):S2
    Content type: Research Published on:

  5. A protein annotation database, such as the Universal Protein Resource knowledge base (UniProtKb), is a valuable resource for the validation and interpretation of predicted 3D structure patterns in proteins. Ex...

    Authors: Kevin Nagel, Antonio Jimeno-Yepes and Dietrich Rebholz-Schuhmann
    Citation: BMC Bioinformatics 2009 10(Suppl 8):S4
    Content type: Research Published on:

  6. The phenotypic effects of sequence variations in protein-coding regions come about primarily via their effects on the resulting structures, for example by disrupting active sites or affecting structural stabil...

    Authors: Jose MG Izarzugaza, Anja Baresic, Lisa EM McMillan, Corin Yeats, Andrew B Clegg, Christine A Orengo, Andrew CR Martin and Alfonso Valencia
    Citation: BMC Bioinformatics 2009 10(Suppl 8):S5
    Content type: Research Published on:

  7. Single nucleotide polymorphisms (SNPs) are the most frequent type of sequence variation between individuals, and represent a promising tool for finding genetic determinants of complex diseases and understandin...

    Authors: Anna Bauer-Mehren, Laura I Furlong, Michael Rautschka and Ferran Sanz
    Citation: BMC Bioinformatics 2009 10(Suppl 8):S6
    Content type: Research Published on:

  8. Human mitochondrial DNA (mtDNA) variations have been implicated in a broad spectrum of diseases. With over 3000 mtDNA variations reported across databases, establishing pathogenicity of variations in mtDNA is ...

    Authors: Anshu Bhardwaj, Mitali Mukerji, Shipra Sharma, Jinny Paul, Chaitanya S Gokhale, Achal K Srivastava and Shrish Tiwari
    Citation: BMC Bioinformatics 2009 10(Suppl 8):S7
    Content type: Research Published on:

  10. Linking structural effects of mutations to functional outcomes is a major issue in structural bioinformatics, and many tools and studies have shown that specific structural properties such as stability and res...

    Authors: Joke Reumers, Joost Schymkowitz and Fréderic Rousseau
    Citation: BMC Bioinformatics 2009 10(Suppl 8):S9
    Content type: Research Published on:

  11. The reaction of HIV protease to inhibitor therapy is characterized by the emergence of complex mutational patterns which confer drug resistance. The response of HIV protease to drugs often involves both primar...

    Authors: Omar Haq, Ronald M Levy, Alexandre V Morozov and Michael Andrec
    Citation: BMC Bioinformatics 2009 10(Suppl 8):S10
    Content type: Research Published on:
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