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Table 1 Relative changes of the signalling characteristics of "Zp" in the small cascade model.

From: TIde: a software for the systematic scanning of drug targets in kinetic network models

Target

Amplitude

Integrated signal

σ

τ

reaction_1

-0.02738

44.05890

14.57600

23.23040

reaction_2

-0.03430

-7.29018

-1.94723

-3.11361

reaction_3

0.04522

15.52320

4.26640

7.72552

reaction_4

-0.02467

-6.55773

-1.81591

-2.67058

reaction_5

0.02314

14.16874

4.16209

7.20750

reaction_6

-0.05883

-7.17961

-1.63696

-2.08881

reaction_7

-0.01467

10.28007

3.47335

5.24139

reference

1.57415

59.36095

18.85494

32.83275

  1. The values in the table depict the relative changes of the characteristics after noncompetitive inhibition of a certain reaction by 50% compared to the reference state.