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Figure 6 | BMC Bioinformatics

Figure 6

From: Comparative analysis of the JAK/STAT signaling through erythropoietin receptor and thrombopoietin receptor using a systems approach

Figure 6

The JAK/STAT pathway. Each node indicates the component involving the transduction signaling or negative regulation of the pathway (R: receptor, JAK: JAK2, RJ: receptor-JAK2 complex, Ligand: Epo or Tpo, LRJ: ligand bound RJ, Pc: cytoplasmic phosphatase, Pn: nuclear phosphatase, SOCS: negative regulator). * and D denote a phosphorylation and a dimerization, respectively. According to the location in a cell, each molecule is tagged by c (cytoplasm) or n (nucleus). The system output was calculated by the level of nuclear phosphorylated STAT dimers (STAT*Dn).

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BMC Bioinformatics

ISSN: 1471-2105

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