Linking genotype to phenotype with Bayesian network modeling of Chlamydia infection
© Ziebarth et al; licensee BioMed Central Ltd. 2010
Published: 23 July 2010
Understanding the causal pathways that link genotypes with gene expression and higher order phenotypes, such as disease susceptibility, has been a recent goal of systems genetic studies. Pairwise correlations can select genes and phenotypes that are associated with a common genetic locus; however, the directions of these links are more difficult to determine. We propose a method in which Bayesian networks are used to establish causal pathways from genotype to gene expression to phenotype and apply it to mice infected with Chlamydia psittaci.
This work was support by NIH grant AI081050 and DOD grant W81XHW-05-01-0227.
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