|
Score
|
P
cluster
|
Cytoband
|
Start (KB)
|
End (KB)
|
# of PA
|
Gene Symbol§
|
|---|
|
-363
|
0
|
9p21.3,p22.1
|
19,639
|
24,327
|
42
|
CDKN2A
|
|
266
|
0
|
7p11.2
|
54,145
|
55,790
|
25
|
EGFR
|
|
101
|
0
|
4q12
|
52,600
|
55,926
|
9
|
PDGFRA
|
|
66
|
0
|
1q32.1
|
200,858
|
202,110
|
5
|
MDM4†
|
|
60
|
0
|
12q15
|
67,074
|
68,482
|
6
|
MDM2
|
|
36
|
0.015
|
12q13.3,q14.1
|
55,820
|
57,257
|
4
|
CDK4
|
|
-35
|
0
|
13q14.2
|
46,386
|
47,510
|
3
|
RB1†
|
|
23
|
0.067
|
7q31.2
|
115,813
|
116,895
|
2
|
MET
|
|
-18
|
0
|
10q23.2,q23.31
|
88,974
|
89,943
|
3
|
PTEN
|
|
-16
|
0
|
19q13.2,q13.31
|
46,084
|
48,423
|
3
| |
|
-15
|
0
|
9p21.1
|
32,101
|
32,432
|
3
| |
|
8
|
0.001
|
17q22
|
47,672
|
49,744
|
2
| |
|
-7
|
0.034
|
1p33
|
50,351
|
50,689
|
2
| |
|
6
|
0
|
2p24.3
|
15,746
|
16,670
|
2
|
MYCN
|
|
-4
|
0
|
9p13.1
|
38,288
|
39,006
|
3
|
IGFBPL1
|
|
2
|
0.005
|
14q31.3
|
84,913
|
86,323
|
2
| |
|
-2
|
0
|
9p12
|
40,722
|
41,675
|
3
| |
|
-0.5
|
0
|
3p14.2
|
60,046
|
60,153
|
2
| |
|
-0.2
|
0.033
|
14q21.2,q21.3
|
42,887
|
43,214
|
2
| |
- 19 statistically significant clusters obtained from the HIGH analysis are shown when M = 12. 'Score' is the sum of
values for positions in the cluster. 'Pcluster' is the statistical significance of the cluster. Positive (negative) values represent that a cluster contains amplified (deleted) focal aberrations. Clusters are ordered by the absolute value of the score. Cytoband, the start and end positions of cluster regions, the number of patients with focal aberrations (# of PA), and GBM or cancer related genes included in the cluster are indicated.
- §Gene annotations are based on hg18 human genome assembly.
- †These genes are closely located to the focal aberrations. MDM4 is located at chr1:202,752-202,794 KB, and RB1 at chr13:47,775-47,954 KB.
values for positions in the cluster. 'Pcluster' is the statistical significance of the cluster. Positive (negative) values represent that a cluster contains amplified (deleted) focal aberrations. Clusters are ordered by the absolute value of the score. Cytoband, the start and end positions of cluster regions, the number of patients with focal aberrations (# of PA), and GBM or cancer related genes included in the cluster are indicated.