Summary of splice site generation and protein modification. This figure summarizes the categories of transcript structures modified by the generation of novel splice acceptors (A) and donors (B) in human proteins. The left column shows a summary of the modification with the category codes A1–D10. The center column shows a schematic of the transcript and coding region structures. Novel splice sites are marked by asterisks. The ancestral coding regions (black), derived coding regions (grey), alternative coding regions (hatched), and untranslated regions (white) are represented by boxes with different patterns. The last column “count” shows the number of cases reported in this study.