Figure 1

Gentrepid architecture and web interface overview. Users input data as a disease locus or loci, and a phenotype, if available (1). Selected loci and known genes (if applicable) are displayed on the overview page (2), from which a CPS or CMP analysis can be initiated (3). The interactive Gentrepid web server matches candidate genes against known disease genes using pre-calculated similarity scores from the annotation engine and displays the results (4), or uses the ab initio search for enrichment of common gene annotations.