Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, et al: Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011, 43 (5): 436-441. 10.1038/ng.801.
Article
PubMed Central
CAS
PubMed
Google Scholar
Haines JL, Hauser MA, Schmidt S, Scott WK, Olson LM, Gallins P, Spencer KL, Kwan SY, Noureddine M, Gilbert JR, et al: Complement factor H variant increases the risk of age-related macular degeneration. Science. 2005, 308 (5720): 419-421. 10.1126/science.1110359.
Article
CAS
PubMed
Google Scholar
McCarthy MI, Abecasis GR, Cardon LR, Goldstein DB, Little J, Ioannidis JP, Hirschhorn JN: Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet. 2008, 9 (5): 356-369. 10.1038/nrg2344.
Article
CAS
PubMed
Google Scholar
Anney RJ, Kenny EM, O'Dushlaine C, Yaspan BL, Parkhomenka E, Buxbaum JD, Sutcliffe J, Gill M, Gallagher L, The Autism Genome P, et al: Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders. Eur J Hum Genet. 2011, 19 (10): 1082-1089. 10.1038/ejhg.2011.75.
Article
PubMed Central
CAS
PubMed
Google Scholar
Braun R, Buetow K: Pathways of Distinction Analysis: A New Technique for Multi-SNP Analysis of GWAS Data. PLoS Genet. 2011, 7 (6): e1002101-10.1371/journal.pgen.1002101.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yaspan BL, Bush WS, Torstenson ES, Ma D, Pericak-Vance MA, Ritchie MD, Sutcliffe JS, Haines JL: Genetic analysis of biological pathway data through genomic randomization. Hum Genet. 2011, 129 (5): 563-571. 10.1007/s00439-011-0956-2.
Article
PubMed Central
PubMed
Google Scholar
Goeman JJ, Buhlmann P: Analyzing gene expression data in terms of gene sets: methodological issues. Bioinformatics. 2007, 23 (8): 980-987. 10.1093/bioinformatics/btm051.
Article
CAS
PubMed
Google Scholar
Wang K, Li M, Hakonarson H: Analysing biological pathways in genome-wide association studies. Nat Rev Genet. 2010, 11 (12): 843-854. 10.1038/nrg2884.
Article
CAS
PubMed
Google Scholar
Chen LS, Hutter CM, Potter JD, Liu Y, Prentice RL, Peters U, Hsu L: Insights into colon cancer etiology via a regularized approach to gene set analysis of GWAS data. Nat Rev Genet. 2010, 86 (6): 860-871.
CAS
Google Scholar
Wang K, Li M, Bucan M: Pathway-based approaches for analysis of genomewide association studies. Nat Rev Genet. 2007, 81 (6): 1278-1283.
CAS
Google Scholar
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, et al: PLINK: a tool set for whole-genome association and population-based linkage analyses. Nat Rev Genet. 2007, 81 (3): 559-575.
CAS
Google Scholar
Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Nat Rev Genet. 1993, 52 (3): 506-516.
CAS
Google Scholar
Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, Haussler D: The human genome browser at UCSC. Genome Res. 2002, 12 (6): 996-1006.
Article
PubMed Central
CAS
PubMed
Google Scholar
Martin ER, Monks SA, Warren LL, Kaplan NL: A test for linkage and association in general pedigrees: the pedigree disequilibrium test. Am J Hum Genet. 2000, 67 (1): 146-154. 10.1086/302957.
Article
PubMed Central
CAS
PubMed
Google Scholar
Laird NM, Horvath S, Xu X: Implementing a unified approach to family-based tests of association. Genet Epidemiol. 2000, 19 (Suppl 1): S36-S42.
Article
PubMed
Google Scholar
Gui H, Li M, Sham PC, Cherny SS: Comparisons of seven algorithms for pathway analysis using the WTCCC Crohn's Disease dataset. BMC Res Notes. 2011, 4: 386-10.1186/1756-0500-4-386.
Article
PubMed Central
PubMed
Google Scholar
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005, 102 (43): 15545-15550. 10.1073/pnas.0506580102.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang K, Li M, Bucan M: Pathway-Based Approaches for Analysis of Genomewide Association Studies. Am J Hum Genet. 2007, 81 (6): 1278-1283. 10.1086/522374.
Article
PubMed Central
CAS
PubMed
Google Scholar
Monks SA, Kaplan NL: Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus. Am J Hum Genet. 2000, 66 (2): 576-592. 10.1086/302745.
Article
PubMed Central
CAS
PubMed
Google Scholar
Benjamini Y, Hochberg Y: Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing. J R Stat Soc Ser B Methodol. 1995, 57 (1): 289-300.
Google Scholar
Edwards TL, Bush WS, Turner SD, Dudek SM, Torstenson ES, Schmidt M, Martin E, Ritchie MD: Generating Linkage Disequilibrium Patterns in Data Simulations using genomeSIMLA. Lect Notes Comput Sci. 2008, 4973 (2008): 24-35.
Article
Google Scholar
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, et al: Finding the missing heritability of complex diseases. Nature. 2009, 461 (7265): 747-753. 10.1038/nature08494.
Article
PubMed Central
CAS
PubMed
Google Scholar