BioTile, A Perl based tool for the identification of differentially enriched regions in tiling microarray data

BMC Bioinformatics

Table 2 Algorithm performance in biological datasets

Dataset	Interrogated mark	# group 1	# group 2	BioTile	TileMap	CHARM
					# DERs returned
1	H3K9me3	12	9	5,315	62	83
2	DNA methylation	6	9	5,767	27	105
3	DNA methylation	10	9	5,558	821	100
					Proportion of validated DERs found
1	H3K9me3	12	9	100%	28%	0%
2	DNA methylation	6	9	100%	9%	0%
3	DNA methylation	10	9	100%	9%	0%
					Proportion of validated DERs significant
1	H3K9me3	12	9	71%	28%	0%
2	DNA methylation	6	9	45%	9%	0%
3	DNA methylation	10	9	55%	9%	0%

A table depicting algorithm performance when applied to datasets derived from the McGowan et al., and Suderman et al., studies investigating the effects of early life environmental influence on epigenetic marks in the hippocampus.

ISSN: 1471-2105