Figure 2

Compressed overview. The overview compresses letters into thin vertical bars to enable visualization over a wide section of a logo. Here, we show positions 51 to 160 of the HMM shown in Figure 1. The color of each bar matches the color of the letter represented by that bar. The active sites of this Caspase domain are found at positions 75 (Histidine, shown as the tall brown bar surrounded by yellow bars to the left) and 127 (Cysteine, shown as the taller turquoise bar to the right). The positions around 150 are located in a surface-exposed loop, so it is not surprising to see that they have low sequence conservation and occupancy, and that some have a high insert probability and expected insert length. Below the logo is a table of residue and gap probabilities for position 75, shown as a result of clicking on the corresponding stack – it shows that Histidine (H) is most common, followed by Lysine (K) and Arginine (R).