Determinants of protein evolutionary rates in light of ENCODE functional genomics
© Kryuchkova and Robinson-Rechavi; licensee BioMed Central Ltd. 2014
Published: 11 February 2014
The influence of different parameters, from gene size to expression levels, on the evolution of proteins has been previously studied mostly in yeast  and Drosophila . The main feature which has been found to explain protein evolutionary rate was the level of gene expression, especially in yeast.
Dependencies between gene features need to be taken into account for an unbiased view of gene evolution. Overall results are consistent with those in Drosophila . We find important differences between tissues in the relation between expression and evolutionary rate, especially for the central nervous system and testis.
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