Figure 4
From: Domain fusion analysis by applying relational algebra to protein sequence and domain databases
The percentage of DFTs to the number of functional linkages in S. cerevisiae (blue) and H. sapiens (red) As expected, the general distribution of the S. cerevisiae and H. sapiens are almost identical. Some DFTs such as ig and SH3 in H. sapiens and rrm and pkinase in S. cerevisiae predict over 5,000 functional linkages. These DFTs are promiscuous and should be removed from the analysis because they predict functional linkages between proteins that are likely unrelated. In the analysis we applied a stringent definition of a promiscuous DFT – those being involved in greater than 10 predicted functional linkages.