Satellog: A database for the identification and prioritization of satellite repeats in disease association studies

Table 1 Unstable coding repeats organized by descending standard deviation Sample output from Satellog.

unit	length	gene location	pep	name	mean	sd
GCA	23	cds	LQQQQQQQQQQQQQQQQQQQQQQQ	AR	20.36	4.11
CAG	15	cds	QQQQQQQQQQQQQQQH	DRPLA	12.44	3.9
GGC	17	cds	GGGGGGGGGGGGGGGGGE	AR	15.1	3.54
CAG	19	cds	QQQQQQQQQQQQQQQQQQQQ	TBP	17.1	3.01
ACC	13	cds	LPPPPPPPPPPPPP	NULL	11.5	2.12
GGC	8	cds	GGGGGGGGG	GDF7	9	1.73
CTG	6	cds	GSSSSSR	PCDH12	7.2	1.55
CCG	9	cds	PAAAAAAAAA	NULL	6	1.41
GGGGCC	4	cds	APAPAPAPAP	CDKN1C	3.33	1.15
GGC	6	cds	GGGGGG	NULL	6.67	1.03

The ten most unstable coding repeats organized by descending standard deviation. Repeats highlighted in bold are known disease-associated repeats. (Note: trailing non-consensus amino acids are not artefactual output. Repeat units continue to be detected at the DNA level even it they do not completely achieve the consensus. For example in the second row above, the corresponding DNA sequence (CAG)₁₅ CA contains a trailing CA (of the subsequent CAT codon) that translates into histidine).

ISSN: 1471-2105