Computational verification of protein-protein interactions by orthologous co-expression

BMC Bioinformatics

Table 2 S. cerevisiae and orthologous co-expression of hypothetical Protein interactions

GENE 1	GENE 2	*S. cerevisiae* Co-expression		Orthologous Co-expression
		correlation	p-value	*D. melanogaster*	*C. elegans*	*H. sapiens*	p-value
TAF5	PIF1	-0.05	0.67	0.74	0.05	0.42	8.7e-04
COR1	XDJ1	-0.01	0.52	*	0.43	0.39	5.0e-03
PUS2	LPD1	-0.06	0.71	*	0.23	0.55	6.1e-03
TAF6	PUB1	0.00	0.49	0.04	0.41	0.50	3.3e-03
PAN3	YNL092W	-0.04	0.64	0.77	0.25	*	1.9e-03
SMT3	TOP2	-0.08	0.77	*	0.47	0.69	9.6e-04

* denotes that at least one of the corresponding orthologs did not have expression data.

ISSN: 1471-2105