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  • Oral presentation
  • Open Access

Transcription regulation: a genomic network

BMC Bioinformatics20056 (Suppl 3) :S1

  • Published:


  • Regulatory Network
  • Gene Expression Level
  • Regulatory System
  • External Stimulus
  • Computational Study

The transcriptional regulatory system plays a central role in directing gene expression changes in response to internal and external stimuli. In this talk, I will present our group's computational studies on transcription regulation in yeast, ranging from large-scale experimental studies to computational analyses of regulatory networks. In the first half I will introduce results from ChIp-chip experiments that identify genome-wide DNA-binding sites of transcription factors, particularly focusing on the cell cycle regulatory system. In the second half I will discuss how these observations fit in with the idea of a genomic regulatory network, and examine the effects of such networks on gene expression levels. Finally, I will introduce the concept of dynamic network usage in the context of transcription regulation, and how specific regulatory pathways are employed to bring about these transitions.

Authors’ Affiliations

European Bioinformatics Institute (EBI), EMBL Outstation, Hinxton, Cambridge, UK


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© Author(s); licensee BioMed Central Ltd. 2005