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Transcription regulation: a genomic network

The transcriptional regulatory system plays a central role in directing gene expression changes in response to internal and external stimuli. In this talk, I will present our group's computational studies on transcription regulation in yeast, ranging from large-scale experimental studies to computational analyses of regulatory networks. In the first half I will introduce results from ChIp-chip experiments that identify genome-wide DNA-binding sites of transcription factors, particularly focusing on the cell cycle regulatory system. In the second half I will discuss how these observations fit in with the idea of a genomic regulatory network, and examine the effects of such networks on gene expression levels. Finally, I will introduce the concept of dynamic network usage in the context of transcription regulation, and how specific regulatory pathways are employed to bring about these transitions.


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Correspondence to Nicholas Luscombe.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Luscombe, N. Transcription regulation: a genomic network. BMC Bioinformatics 6 (Suppl 3), S1 (2005).

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