Table 1 Number of enzyme hits identified in six common cancer types using the combined data mining strategy.a
From: A combined approach to data mining of textual and structured data to identify cancer-related targets
Tumor type | Prostate | Breast | Lung | Colon | Ovary | Pancreas |
|---|---|---|---|---|---|---|
PubMed: Abstracts about tissue types | 89839 b | 20393 8 | 644380 | 133660 | 147373 | 164890 |
LSGraph: Abstracts with entity-to-entity functional relations in different tumor-tissue types (function «filter») | 10857 | 23875 | 42962 | 15808 | 24758 | 28356 |
LSGraph: Abstracts remaining after filtering for keywords «extracellular» or «membrane» | 1784 | 3873 | 8869 | 4815 | 4683 | 5305 |
LSGraph: All cited entities retrieved from filtered abstracts (function «Most cited entities») | 1791c | 2500 | 4325 | 3030 | 3365 | 3059 |
LSGraph: Entities filtered additionally by Gene Ontology (function «Best GO») with the cellular component «extracellular region» or «membrane». Exported to IPA through UniProt accession numbers | 749 | 941 | 1718 | 1186 | 1427 | 1244 |
IPA: Imported entities overlaid onto a global molecular network of IPA and enlarged by functionally related entities | 917 | 1117 | 1954 | 1408 | 1675 | 1495 |
IPA: Entities within the network «cancer»d | 375 | 456 | 598 | 481 | 515 | 450 |
   IPA-location: Extracellular space | 135 | 170 | 212 | 176 | 184 | 170 |
   IPA-location: Plasma membrane | 188 | 220 | 298 | 238 | 262 | 219 |
   IPA-location: Extracellular space and Plasma membrane | 323 | 390 | 510 | 414 | 446 | 389 |
   IPA-family: Enzymes | 12 | 14 | 20 | 17 | 16 | 16 |
   IPA-family: Peptidases | 24 | 25 | 33 | 24 | 30 | 31 |
   IPA-family: Phosphatases | 5 | 9 | 10 | 7 | 8 | 5 |
   Other IPA-familiese | 282 | 342 | 447 | 366 | 392 | 337 |