Reuse of structural domain–domain interactions in protein networks

BMC Bioinformatics

Table 1 iPfam domain pair coverage on protein interactions

Species	Proteins in proteome	% proteome in interaction set	Protein pairs in interaction set	Protein pairs with iPfam domain pair	Protein pairs with iPfam domain pair (randomised mean)	Standard deviation
E. coli	4314	26.96%	1281	211	178	7.12
S. cerevisiae	5780	92.72%	45707	2045	528	57.49
C. elegans	22437	13.47%	5310	221	76	9.90
D. melanogaster	16251	43.22%	21921	641	195	21.79
H. sapiens	38213	21.40%	24065	4577	1373	116.86

For each species, we list the size of the proteome as defined in Integr8 and the fraction of this proteome that is represented in the protein interaction sets, followed by the total number of binary protein interactions and the fraction of those that contain an i Pfam domain pair. The last two columns show the results of the network shuffling experiments.

ISSN: 1471-2105