Figure 3
From: Normalization method for metabolomics data using optimal selection of multiple internal standards
Coefficient of variance distributions for different normalization methods. Data shown is based on mouse liver run of 16 samples under repeability conditions (3 extractions from the same biological sample, each with repeated runs of 10, 3, and 3 injections, respectively). Total 1470 monoisotopic peaks were included in the analysis. The NOMIS method has a notably narrower CV distribution than raw data and other normalization methods, with lower median CV (MCV).