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Figure 6 | BMC Bioinformatics

Figure 6

From: From biophysics to evolutionary genetics: statistical aspects of gene regulation

Figure 6

Evolution of genotype composition x ( t ). (a) Deterministic evolution with fitness difference ΔF ab > 0, leading to certain fixation of genotype b (time is shown in units of τ d = 1/ΔF ab ). (b) Stochastic evolution with selection and genetic drift, leading to fixation of one of the genotypes. The time to fixation (grey shading) is of order τ s (N ΔF ab = 0.5, time is shown in units of N). (c) Stochastic evolution with selection, genetic drift, and mutations in the regime 1, leading to a substitution dynamics with rates uaband ubagiven by (49). Substitution events are marked by dashed lines. The typical time between initial mutation and fixation (grey shading) for a given substitution, τ s , is much shorter than the time between subsequent substitutions, 1/uabresp. 1/uba(N ΔF ab = 0.5, = 0.05, time is shown in units of 1/μ).

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