Figure 6

Visualization of several parts of different pathway layouts of the iAF1260 model. A simulation comparison of the wild-type simulation and a mutant that produces glycine, was performed, which allows the visualization of fluxes differences in both simulations. A part of central metabolism pathway, showing the inactivation of the phosphoenolpyruvate carboxylase (R_PPC); B another component of the central metabolism pathway showing the inactivation of the isocitrate lyase (R_ICL); C part of the alternate carbon souirces pathway that clearly shows an increase in flux for the mutant simulation. D part of the co-factor biosynthesis pathway showing the inactivation of the glycine cleavage (R_GLYCL); E and F parts of the nucleotide metabolism pathway and inactivation of the phosphoribosylglycinamide formyltransferase 2 (R_GART).