Overview of DECODE. (i) Calculating DE for every gene. (ii) Consider every individual gene i in turn, calculating DC between gene i with every other genes. Genes are represented by nodes. Higher DC between a gene and gene i is illustrated using longer edge. (iii) Selecting optimal thresholds to define high/low DE and high/low DC based on chi-square maximization. Genes with higher DE are illustrated by shading with deeper red colour. (iv) Evaluate functional relevance of selected gene partitions based on functional gene sets.