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Table 2 Properties of PfCelTOS, human IL-2 and designed constructs determined by ProtParam

From: Design, structure prediction and molecular dynamics simulation of a fusion construct containing malaria pre-erythrocytic vaccine candidate, PfCelTOS, and human interleukin 2 as adjuvant

Protein PfCelTOS Fusion protein1 Fusion protein2
(IL-2-linker-PfCelTOS) (Co1-linker-IL-2-linker-PfCelTOS)
No. of amino acids 173 321 348
Molecular weight 19087.4 35433.2 38176.4
Theoretical pI 4.58 5.11 5.32
Total No. of negatively charged residues (Asp + Glu) 23 38 41
Total No. of positively charged residues (Arg + Lys) 13 28 32
Formula C855H1326N212O274S4 C1581H2495N405O494S11 C1703H2691N441O530S11
Instability index 41.67 48.01 49.75
Aliphatic index 89.48 91.06 89.11
Grand average of hydropathicity (GRAVY) −0.106 −0.151 −0.172