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Fig. 7 | BMC Bioinformatics

Fig. 7

From: ReTrOS: a MATLAB toolbox for reconstructing transcriptional activity from gene and protein expression data

Fig. 7

Back-calculated transcription profiles of the wild-type and cry1 cry2 double-mutant CCR2 reporter lines under different temperature and light conditions. Each panel shows the back-calculated wild-type CCR2 (black line) and the double-mutant cry1 cry2 CCR2 (red line) transcription profiles at 12 (top row), 17 (middle row) and 27 °C (bottom row) with blue (BL, left column), mixed red and blue (RBL, middle column) and red light (RL, right column) conditions. The rhythmic activity is observable in all profiles, but with strong damping at 17 and 27 °C across most light conditions. A lengthening of oscillatory period is particularly observable in the mutant line at 27 °C under RBL conditions. Degradation rates (mean, std. dev.) of mRNA and protein are respectively (2.8, 0.63) and (0.098, 0.0058) at 12 °C, (2.3, 0.46) and (0.13, 0.010) at 17 °C, and (1.2, 0.11) and (0.19, 0.020) at 27 °C. For other parameter values, see the middle panel of Fig. 5

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