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Fig. 6 | BMC Bioinformatics

Fig. 6

From: An integrated approach to infer cross-talks between intracellular protein transport and signaling pathways

Fig. 6

Regulatory interactions between PI3K-Akt signaling and intracellular protein transport. Genes enriched in PI3K-Akt signaling pathway are represented by diamond shape in pink color such as IL7R,TNN, ITGB4, CSF1R, STK11, ITGB1, ITGB7, FGF17, COL5A3, PDGFRA, PP2R3A, AKT1, HSP90AA, CCND1 and PTEN and YWHAZ. These genes are regulated by the perturbation in CSNK1D, TSC2, PML, SHH, KDR and SGK1 gene represented by oval shape in red color. Out of these perturbed genes, KDR, SGK1 and TSC2 also plays an important role in PI3K-Akt signaling; and they are represented by diamond shape and in red color. The edges with arrow signs represent the four fold increase in the expression of target/effected genes, while edges with dot represent the four fold down-regulation

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BMC Bioinformatics

ISSN: 1471-2105

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