Fig. 7

Ras signaling cross-talk protein transport. The cross regulatory interactions between the components of Ras (represented by diamond shape and in pink color) and intracellular pathways represented by oval shape and in red color. Constituent genes of Ras pathway such as CSF1R, PDGFRA, FGF17, FGFR2, FGFR4, RAP1A, GRB2 and KDR are either regulated by the components of intracellular protein transport or they also regulate each other variably. Some of the components of Ras pathway such as KDR, FGFR4, FGFR2 are also involved in intracellular protein transport mechanism. The edges with arrow signs represent the four fold increase in the expression of target/effected genes, while edges with dot represent the four fold down-regulation