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Table 4 The world-wide PPC coverage of epitope ensemble predicted from all 5 genome derived predicted antigenic adhesins (GDPAA) and 5 randomly selected known malarial adhesins (RSKMA) as well as 151 experimentally known epitopes (EKE) of P. falciparum

From: Exploitation of reverse vaccinology and immunoinformatics as promising platform for genome-wide screening of new effective vaccine candidates against Plasmodium falciparum

S.No. Epitope ensemble PPC for world-wide population (%)
MHC class I MHC class II Combined
1. GDPAA
MHC class I:
FAMSNALLV, ILMLILYSF, YTLTAGVCV, FSSSNNSVY, YEMKFNNNF, LIVCSIFIK, YFNDDIKQF, LLKSYKYIK, SRLKKRKYF, KGMSSSQEM
MHC class II:
IPFFILHILLLQFLL, FIQLYITLNKARVTE, TCGNGIQVRIKPGSA
99.53 93.71 99.97
2. RSKMA
MHC class I:
YFFASFFVL, FTYDSEEYY, FAFPPTEPL, FMPPRRQHF, FRDEWWKVI, RIYDKNLLM, KLYFPTPAL, YAFSEECPY, ISFQNYTYL
MHC class II:
DKMKIIIASSAAVAV, YKYAASFTLAAILFL
98.67 92.31 99.90
3. EKE of P. falciparum
MHC class I:
RPRGDNFAV, TPYAGEPAPF, YLINKHWQR, NQMIFVSSI, KVSDEIWNY
MHC class II:
DAEVAGTQYRLPSGKCPVFG, LKELIKVGLPSFENL, ALLIIPPKIHISIEL
90.78 75.31 97.72