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Fig. 1 | BMC Bioinformatics

Fig. 1

From: An integrative methodology based on protein-protein interaction networks for identification and functional annotation of disease-relevant genes applied to channelopathies

Fig. 1

Semi-automatic workflow for the identification and functional annotation of the most relevant genes in a pathology. Stage 1) Phenopedia [30] is a disease-centered view of genetic association studies summarized in the online Human Genome Epidemiology (HuGE) encyclopedia. It provides a list of genes involved in the disease of interest. It is in this stage that a complex disease, a set of diseases or a certain disease can be chosen to be studied. Stage 2) STRING [22] is a database of known and predicted protein-protein interactions that allows the discovery of relationships across disease genotype and thus the creation of the PPI network. Cytoscape [23] is an open source software platform for the visualization and analysis of complex networks that measures each gene and identifies network nodes. Stage 3) DAVID database [24] works as a semi-automatic functional annotation tool of the genes obtained after Stage 2

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BMC Bioinformatics

ISSN: 1471-2105

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